The accident occurred when Patricia Williams, of Jamestown, was traveling North and failed to negotiate a curve.
Williams lost control and her vehicle went into a skid.
The vehicle went across the South bound lane, over embankment and overturned.
Williams was treated by Adair County EMS and transported to T.J. Health Columbia, where she was flown by helicopter to the University of Kentucky Hospital for head injuries.
Deputy Brandon Hitch is investigating the collision.