All nine games kickoff on Saturday for the first time this season. Keiser (Fla.) welcomes No. 9 Georgetown (Ky.) to West Palm Beach, Florida for its first home game in program history. The Seahawks face its second-straight ranked opponent at Noon ET.
In a 1 p.m. ET start, No. 25 Faulkner (Ala.) hosts Cincinnati Christian (Ohio).
At 1:30 p.m. ET, Webber International looks to stay undefeated as they hit the road to face Union (Ky.). Reinhardt (Ga.) plays Ave Maria (Fla.) at home at 1:30 p.m. ET.
Two more games start at 1:30 p.m. ET. Point (Ga.) travels to Campbellsville (Ky.) and Kentucky Christian faces Cumberlands (Ky.) in Grayson, Kentucky.
In a 2:30 p.m. ET start, Edward Waters (Fla.) visits Cumberland (Tenn.). The Phoenix have not lost at home since the 2016 season opener.
Two ranked teams square off at 4:30 p.m. ET. No. 17 Bethel (Tenn.) travels to face No. 18 Southeastern (Fla.). The Wildcats are looking to move to 2-0 against top 25 opponents this season.
To round out week five, Bluefield (Va.) travels to FCS Presbyterian (S.C.) at 7 p.m. ET.
Last week, 20 teams from the Mid-South Conference were in action.
Georgetown picked up its second win of the season with a 24-7 win over St. Andrews (N.C.). The Tigers limited the Knights to 60 yards of passing on the night.
Nine more games were played on Saturday, as Cumberland used a fourth-quarter comeback to slip past Ave Maria, 35-34. The Phoenix outscored the Gyrenes 14-0 in the final frame.
Faulkner raced past Union, 42-20 in its home opener last Saturday. Southeastern picked up a 58-14 win over Cincinnati Christian on the road.
Point earned its first win of the season with a 28-24 defeat of Kentucky Christian. Isaiah McFarland intercepted three passes on his way to winning MSC Appalachian Defensive Player of the Week.
Bethel handed Keiser its first loss of the season, 52-7. The Wildcats held the Seahawks to under 200 yards of total offense on the afternoon.
Reinhardt outgained Warner, 293-88 on the ground in its 49-7 win over the Royals. Lindsey Wilson racked up 661 yards of total offense in its 69-14 victory against Pikeville.
Cumberlands' Milton Shelton rushed for 213 yards and a pair of touchdowns in the Patriots' 35-21 win over Campbellsville. To round out week four, Webber International moved to 3-0 for the first time in program history after slipping past Bluefield, 16-8.
The second regular-season Coaches poll was released on Monday and seven MSC teams are ranked heading into the week -- Lindsey Wilson (4th), Reinhardt (7th) Georgetown (9th), Cumberlands (16th), Bethel (17th), Southeastern (18th), and Faulkner (25th).
Webber International is mentioned in the receiving votes section of the poll.